TY - GEN AU - Buxbaum, Engelbert TI - Fundamentals of protein structure and function [2nd ed.] [Perpetual] SN - 9783319199207 U1 - 572 PY - 2015/// CY - Heidelberg PB - Springer KW - Proteins -- Structure KW - Biochemistry N2 - This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion of how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological, and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments, and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure, and molecular interactions. The book emphasises the link between protein structure, physiological function, and medical significance UR - https://link.springer.com/book/10.1007/978-3-319-19920-7 ER -