000			02205 a2200337 4500
003			OSt
005			20220131160633.0
008			220128b xxu||||| |||| 00| 0 eng d
020			_a9783030898724
040			_cIIT Kanpur
041			_aeng
082			_a547 _bP943
245			_aProgress in the chemistry of organic natural products [Vol.117] _bantimalarial natural products _cDavid G. I. Kingston and Maria Belen Cassera ; edited by A. Douglas Kinghorn ...[et al.]
260			_bSpringer _c2022 _aSwitzerland
300			_aix, 106p
440			_aProgress in the chemistry of organic natural products
490			_a / edited by A. Douglas Kinghorn ...[et al.] ; v.117
520			_aThis volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
650			_aAntimalarials
650			_aNatural products
650			_aChemistry, Organic
700			_aKingston, David G. I.
700			_aCassera, Maria Belen
700			_aKinghorn, A. Douglas [ed.]
700			_aFalk, Heinz [ed.]
700			_aGibbons, Simon [ed.]
700			_aAsakawa, Yoshinori [ed.]
700			_aLiu, Ji-Kai [ed.]
700			_aDirsch, Verena M. [ed.]
942			_cBK
999			_c565389 _d565389