000			02140 a2200361 4500
003			OSt
005			20230306125112.0
008			230303b xxu||||| |||| 00| 0 eng d
020			_a9783031104565
040			_cIIT Kanpur
041			_aeng
082			_a547 _bP943 v.119
245			_aProgress in the chemistry of organic natural products [Vol. 119] _bancistrocladus naphthylisoquinoline alkaloids _cedited by A. Douglas Kinghorn ... [et al.]; Doris Feineis and Gerhard Bringmann
260			_bSpringer _c2023 _aSwitzerland
300			_axi, 335p
440			_aProgress in the chemistry of organic natural products
490			_a/ edited by A. Douglas Kinghorn... [et al.] _vv.119
520			_aThis book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
650			_aNatural products
650			_aChemistry, Organic
650			_aAncistrocladus
650			_aNaphthylisoquinoline
650			_aAlkaloids
700			_aKinghorn, A. Douglas [ed.]
700			_aFalk, Heinz [ed.]
700			_aGibbons, Simon [ed.]
700			_aAsakawa, Yoshinori [ed.]
700			_aLiu, Ji-Kai [ed.]
700			_aDirsch, Verena M. [ed.]
700			_a Feineis, Doris
700			_aBringmann,Gerhard
942			_cBK
999			_c566471 _d566471